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Metabolism Diazepam is N-demethylated by CYP3A4 and 2C19 to your active metabolite N-desmethyldiazepam, and is particularly hydroxylated by CYP3A4 into the active metabolite temazepam.If you have been applying benzodiazepines for a shorter period, cut down your use gradually around a few days. This tends to considerably lower any unpleasant milder